удк 611–018.58:612. 67

 

 Entropy of leukocyte formula as biological

ageing marker

 

(bazhenov-3i.doc)

 

Ó 2007. Golovanova E. D., Dubenskaya L. I., Bazhenov S. M.

 

The ageing is characterized by breaches in principal homeostatic systems with leading role of cardio-vascular system and reduce of adaptation possibilities. These abnormalities can be estimated due to entropy methods of leukocyte formula parameters depending on biological ageing rate. High parameters of structural entropy in background of stab neutrophilocytes displacement may be additional markers of the fast ageing rate in mature, elderly and senile patients with arterial hypertension.

 

         The ageing is characterized by breaches in principal homeostatic systems with leading role of cardio-vascular system and reduce of adaptation possibilities.

         These abnormalities can be estimated due to entropy methods of biological systems analysis.

         Aim: studying of leukocyte formula parameters depending on biological ageing rate.

         Methods: 167 patients from 25 to 90 years old with arterial hypertension were examined. They were divided into 2 groups. In the first subgroup of 72 patients average age was 49,1±5,8, in the second subgroup of 95 patients average age was 76,8±5,3 years.

         Biological ageing rate was counted on application of multiple linear regression analysis with the use of clinical and physiological markers.

         The relative entropy of leukocyte formula (RELF) was estimated by Shannon C.:

                                                                            n

                                    H= – ∑    (ai ∕ 100)x log2 (ai ∕ 100),

                                                                           i=1

where H – RELF in relative units; i=1,2…n – quantity of specific leukocytes groups in formula of blood, ai – percentage number of i-group leukocytes in formula of blood. The number of entropy shares was found by using special tables. The meanings of relative entropy were expressed in per cent. The meanings of RELF from 56 to 67% were considered adaptive physiological limits.

 

Results and Discussion: Reliable differences of stab neutrophilocytes in according to ageing rate (4,4±2,4 – with slow, 9,12±2,9 – with fast, p<0,001) were revealed statistically. Leukocytes formula entropy depends on ageing rate with mature patients (55,1±5,8% – with slow rate; 59,9±5,0% – with normal, p1<0,05; 67,8±7,2% – with fast, p2<0,001), both in elderly and senile patients (63,4±4,4 –with slow rate, 69,1±5,5 – with fast rate; p<0,01). No significant differences were determined in fast ageing rate between the first and second groups, that points out great influence of cardio-vascular component on ageing rate of mature patients with hypertension.

 

Conclusion – High parameters of structural entropy in background of stab neutrophilocytes displacement may be additional markers of the fast ageing rate in mature, elderly and senile patients with arterial hypertension.

 

Энтропия лейкоцитарной формулы как маркер биологического старения

 

Ó 2007 г. Голованова Е. Д., Дубенская Л. И., Баженов С. М.

 

         В исследовании изучена зависимость энтропии лейкоцитарной формулы крови от темпа биологического старения. Обследовано 167 пациентов с артериальной гипертонией в возрасте от 25 до 90 лет. Выявлены высокие показатели структурной энтропии лейкоцитарной формулы, которые могут являться дополнительными маркерами «ускоренного» темпа биологического старения.

 

 

Central Scientific-Research Laboratory

Smolensk State Medical Academy

 

Центральная научно-исследовательская лаборатория

Смоленская государственная медицинская академия

Поступила в редакцию 29.03.2007.